Hiroya Kondo, Mayaka Maeno, Kazuki Hirano and Norio Shibata
Chem. Commun., 2018,54, 5522-5525
DOI:
10.1039/C8CC03131B,
Communication
The palladium-catalyzed asymmetric decarboxylative allylic alkylation of trifluoromethoxy allyl enol carbonates afforded enantioenriched α-trifluoromethoxy allyl ketones that feature a tetrasubstituted α-stereogenic center in excellent yield and high enantioselectivity. The method was further extended to the asymmetric synthesis of α-difluoromethoxy and α-methoxy allyl ketones, which proceeded under similar catalytic conditions.
