Issue 4, 2013

Detection of single-nucleotide polymorphisms based on the formation of an electron-transfer impeding layer on an electrode surface

Abstract

An electrochemical biosensor utilizing the electron-transfer impeding (insulating) power of a conducting polymer for label-free genotyping single-nucleotide polymorphisms is proposed. Excellent selectivity and sensitivity are accomplished through the engagement of a nuclease clean-up step and a cumulative signal generation/amplification process, respectively.

Graphical abstract: Detection of single-nucleotide polymorphisms based on the formation of an electron-transfer impeding layer on an electrode surface

Article information

Article type
Communication
Submitted
12 Oct 2012
Accepted
13 Nov 2012
First published
27 Nov 2012

Chem. Commun., 2013,49, 370-372

Detection of single-nucleotide polymorphisms based on the formation of an electron-transfer impeding layer on an electrode surface

Z. Gao, W. Shen, H. Deng and Y. Ren, Chem. Commun., 2013, 49, 370 DOI: 10.1039/C2CC37450A

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