Synthesis of peptide-grafted comb polypeptides via polymerisation of NCA-peptides

Hiroshi Enomoto; Benjamin Nottelet; Soultan Al Halifa; Christine Enjalbal; Mathieu Dupré; Julien Tailhades; Jean Coudane; Gilles Subra; Jean Martinez; Muriel Amblard

doi:10.1039/C2CC37597D

Synthesis of peptide-grafted comb polypeptidesviapolymerisation of NCA-peptides†

Hiroshi Enomoto,‡§^a Benjamin Nottelet,§^a Soultan Al Halifa,^a Christine Enjalbal,^a Mathieu Dupré,^a Julien Tailhades,^a Jean Coudane,^a Gilles Subra,^a Jean Martinez^a and Muriel Amblard*^a

Author affiliations

* Corresponding authors

^a Institut des Biomolécules Max Mousseron (IBMM), UMR5247 CNRS, Université Montpellier 1 et 2, 15 avenue Charles Flahault, 34000 Montpellier, France
E-mail: muriel.amblard@univ-montp1.fr
Fax: +33 4 11 75 96 41
Tel: +33 4 11 75 96 05

Abstract

A straightforward synthesis of comb-polypeptides of repeated peptide sequences was developed. These polypeptides were obtained by ROP of defined NCA without any post-polymerization grafting. The key to this strategy relies on the preparation of pure NCA bearing a peptide sequence on its side chain, by an original solid supported methodology.

Chemical Communications

Synthesis of peptide-grafted comb polypeptidesviapolymerisation of NCA-peptides†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Synthesis of peptide-grafted comb polypeptides via polymerisation of NCA-peptides

Social activity

Search articles by author

Spotlight

Advertisements