Issue 14, 2011

Molecular mechanisms of antibiotic resistance

Abstract

Over the past decade, resistance to antibiotics has emerged as a crisis of global proportion. Microbes resistant to many and even all clinically approved antibiotics are increasingly common and easily spread across continents. At the same time there are fewer new antibiotic drugs coming to market. We are reaching a point where we are no longer able to confidently treat a growing number of bacterial infections. The molecular mechanisms of drug resistance provide the essential knowledge on new drug development and clinical use. These mechanisms include enzyme catalyzed antibiotic modifications, bypass of antibiotic targets and active efflux of drugs from the cell. Understanding the chemical rationale and underpinnings of resistance is an essential component of our response to this clinical challenge.

Graphical abstract: Molecular mechanisms of antibiotic resistance

Article information

Article type
Highlight
Submitted
22 Xim 2010
Accepted
07 Qun 2011
First published
01 Nah 2011

Chem. Commun., 2011,47, 4055-4061

Molecular mechanisms of antibiotic resistance

G. D. Wright, Chem. Commun., 2011, 47, 4055 DOI: 10.1039/C0CC05111J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements