Issue 31, 2022

A copper-catalysed one-pot hydroboration/azidation/cycloaddition reaction of alkynes

Abstract

Herein we report our study on the development of a catalytic one-pot process, showing the challenges and advantages encountered all over the way. At the end, we developed a regioselective, environmentally friendly, and operationally simple method to explore the reactivity of functionalized propargylic alkynes through three copper-catalysed reactions in a single reaction vessel. The sequence consisted of a hydroboration, azidation, and 1,3-dipolar cycloaddition and led to the regioselective formation of vinyl 1,2,3-triazoles in good yields.

Graphical abstract: A copper-catalysed one-pot hydroboration/azidation/cycloaddition reaction of alkynes

  • This article is part of the themed collection: New Talent

Supplementary files

Article information

Article type
Paper
Submitted
04 Agd 2022
Accepted
17 Cax 2022
First published
17 Cax 2022

Org. Biomol. Chem., 2022,20, 6239-6244

A copper-catalysed one-pot hydroboration/azidation/cycloaddition reaction of alkynes

H. C. Zimba, L. L. Baldassari and A. V. Moro, Org. Biomol. Chem., 2022, 20, 6239 DOI: 10.1039/D2OB00635A

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