Issue 1, 2014

N-alkylation of indole via ring-closing metathesis/isomerization/Mannich cascade under ruthenium/chiral phosphoric acid sequential catalysis

Abstract

A sequential catalysis by combining the Zhan-1B catalyst with chiral phosphoric acid has been utilized for N-alkylation of indole through a ring-closing metathesis/double bond isomerization/Mannich reaction cascade. Enantioenriched γ-lactams were synthesized in up to 92% yield and 95% ee.

Graphical abstract: N-alkylation of indole via ring-closing metathesis/isomerization/Mannich cascade under ruthenium/chiral phosphoric acid sequential catalysis

Supplementary files

Article information

Article type
Research Article
Submitted
08 Dit 2013
Accepted
25 Dit 2013
First published
23 Kax 2013

Org. Chem. Front., 2014,1, 39-43

N-alkylation of indole via ring-closing metathesis/isomerization/Mannich cascade under ruthenium/chiral phosphoric acid sequential catalysis

Y. Shi, S. Wang, Q. Yin and S. You, Org. Chem. Front., 2014, 1, 39 DOI: 10.1039/C3QO00008G

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