Issue 3, 2014

Palladium-catalyzed cascade cyclization for the construction of spiro-N,O-acetals

Abstract

A facile Pd-catalyzed cascade cyclization of N-alkenylamine and pyruvic acids has been developed to construct spiro-N,O-acetals. This transformation was initiated by an intramolecular oxidative amination of alkenes, followed by hydrolysis to give a ketone intermediate, which further reacts with pyruvic acid to deliver the final spiro-N,O-acetals.

Graphical abstract: Palladium-catalyzed cascade cyclization for the construction of spiro-N,O-acetals

Supplementary files

Article information

Article type
Research Article
Submitted
02 Qun 2014
Accepted
29 Qun 2014
First published
06 Cig 2014

Org. Chem. Front., 2014,1, 289-293

Palladium-catalyzed cascade cyclization for the construction of spiro-N,O-acetals

J. Cheng, P. Chen and G. Liu, Org. Chem. Front., 2014, 1, 289 DOI: 10.1039/C4QO00002A

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