Issue 10, 2014

Conquering three-carbon axial chirality of allenes

Abstract

While one-carbon central chirality of organic molecules has been recognized and extensively studied for more than a century, far less attention has been paid to three-carbon axial chirality of allenes, although they exist in nature with interesting biological activity and have been demonstrated with great synthetic potentials. However, remarkable progress has been made in this field in recent years, giving rise to axially chiral allenes with a wide range of functionalities with practical enantioselectivity. This review provides a concise account of enantioselective syntheses of axially chiral allenes with a selection of published protocols.

Graphical abstract: Conquering three-carbon axial chirality of allenes

Article information

Article type
Review Article
Submitted
25 Qad 2014
Accepted
05 Way 2014
First published
10 Way 2014

Org. Chem. Front., 2014,1, 1210-1224

Conquering three-carbon axial chirality of allenes

J. Ye and S. Ma, Org. Chem. Front., 2014, 1, 1210 DOI: 10.1039/C4QO00208C

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