Christian Greunke, Janine Antosch and Tobias A. M. Gulder
Chem. Commun., 2015,51, 5334-5336
DOI:
10.1039/C5CC00843C,
Communication
Polycyclic tetramate macrolactams (PTMs) are a structurally, biomedically and biosynthetically intriguing class of bacterial metabolites. By combining parts of the machineries of different PTM biosynthetic pathways, we demonstrate for the first time the substrate promiscuity of a class of PTM tailoring enzymes, thereby facilitating the (bio)synthesis of butremycin.