Issue 4, 2015

Cleavage of the C–C triple bond of ketoalkynes: synthesis of 4(3H)-quinazolinones

Abstract

A novel protocol for the synthesis of 4(3H)-quinazolinones via selective cleavage of the triple bond of ketoalkynes under oxidant-, metal-, and ligand-free conditions has been developed. Various 4(3H)-quinazolinones were obtained through fragmentation of the C–C triple bond and formation of two C–N bonds.

Graphical abstract: Cleavage of the C–C triple bond of ketoalkynes: synthesis of 4(3H)-quinazolinones

Supplementary files

Article information

Article type
Research Article
Submitted
05 Dit 2014
Accepted
09 Nah 2015
First published
11 Nah 2015

Org. Chem. Front., 2015,2, 366-368

Author version available

Cleavage of the C–C triple bond of ketoalkynes: synthesis of 4(3H)-quinazolinones

X. Yang, G. Cheng, J. Shen, C. Kuai and X. Cui, Org. Chem. Front., 2015, 2, 366 DOI: 10.1039/C4QO00260A

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