Issue 4, 2015

Cationic iridium-catalyzed C–H alkylation of 2-substituted pyridine N-oxides with acrylates

Abstract

The reaction of 2-arylmethyl-, 2-aryl-, and 2-alkyl substituted pyridine N-oxides with acrylates proceeded in the presence of a cationic Ir-rac-BINAP catalyst under heating conditions. Various 2,6-disubstituted pyridine N-oxides were obtained by C–H alkylation at the C6-position.

Graphical abstract: Cationic iridium-catalyzed C–H alkylation of 2-substituted pyridine N-oxides with acrylates

Supplementary files

Article information

Article type
Research Article
Submitted
30 Kax 2014
Accepted
09 Nah 2015
First published
11 Nah 2015

Org. Chem. Front., 2015,2, 383-387

Author version available

Cationic iridium-catalyzed C–H alkylation of 2-substituted pyridine N-oxides with acrylates

T. Shibata and H. Takano, Org. Chem. Front., 2015, 2, 383 DOI: 10.1039/C4QO00355A

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