Issue 46, 2016

Controlled production of the elusive metastable form II of acetaminophen (paracetamol): a fully scalable templating approach in a cooling environment

Abstract

A scalable, transferable, cooling crystallisation route to the elusive, metastable, form II of the API acetaminophen (paracetamol) has been developed using a multicomponent “templating” approach, delivering 100% polymorphic phase pure form II at scales up to 120 g. Favourable solubility and stability properties are found for the form II samples.

Graphical abstract: Controlled production of the elusive metastable form II of acetaminophen (paracetamol): a fully scalable templating approach in a cooling environment

Supplementary files

Article information

Article type
Communication
Submitted
01 Nah 2016
Accepted
19 Nah 2016
First published
19 Nah 2016
This article is Open Access
Creative Commons BY license

Chem. Commun., 2016,52, 7368-7371

Author version available

Controlled production of the elusive metastable form II of acetaminophen (paracetamol): a fully scalable templating approach in a cooling environment

L. R. Agnew, D. L. Cruickshank, T. McGlone and C. C. Wilson, Chem. Commun., 2016, 52, 7368 DOI: 10.1039/C6CC01032F

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