Issue 32, 2017

Hollow carbon nanospheres for targeted delivery of chemotherapeutics in breast cancer therapy

Abstract

We present novel hollow carbon nanospheres (HCNs) for targeted breast cancer therapy. The HCNs have a 40 nm-cavity for drugs loading, and the surface is covered with “natural” primary amine without any exogenous modification, equipped to conjugate with functional biomolecules. After modification with anti-HER2 antibody and loading of Doxorubicin (DOX) to the HCNs, the HER2@HCNs/DOX can specifically access HER2-positive breast cancer cells and significantly suppress the cells in vitro, causing ∼60% reduction of the volume of the HER2-positive tumours in vivo. The HCNs show great promise to become a multifunctional carrier in the field of high-loading capacity drug delivery for cancer therapy.

Graphical abstract: Hollow carbon nanospheres for targeted delivery of chemotherapeutics in breast cancer therapy

Supplementary files

Article information

Article type
Paper
Submitted
22 Agd 2017
Accepted
17 Cax 2017
First published
17 Cax 2017

J. Mater. Chem. B, 2017,5, 6601-6607

Hollow carbon nanospheres for targeted delivery of chemotherapeutics in breast cancer therapy

L. Zhang, P. Wang, W. Zheng and X. Jiang, J. Mater. Chem. B, 2017, 5, 6601 DOI: 10.1039/C7TB01105A

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