Issue 15, 2019

Sensitivity enhancement in lateral flow assays: a systems perspective

Abstract

Lateral flow assays (LFAs) are rapid, inexpensive, easy-to-manufacture and -use tests widely employed in medical and environmental applications, particularly in low resource settings. Historically, LFAs have been stigmatized as having limited sensitivity. However, as their global usage expands, extensive research has demonstrated that it is possible to substantially improve LFA sensitivity without sacrificing their advantages. In this critical review, we have compiled state-of-the-art approaches to LFA sensitivity enhancement. Moreover, we have organized and evaluated these approaches from a system-level perspective, as we have observed that the advantages and disadvantages of each approach have arisen from the integrated and tightly interconnected chemical, physical, and optical properties of LFAs.

Graphical abstract: Sensitivity enhancement in lateral flow assays: a systems perspective

Article information

Article type
Critical Review
Submitted
30 Qun 2019
Accepted
26 Agd 2019
First published
28 Qas 2019
This article is Open Access
Creative Commons BY-NC license

Lab Chip, 2019,19, 2486-2499

Sensitivity enhancement in lateral flow assays: a systems perspective

J. D. Bishop, H. V. Hsieh, D. J. Gasperino and B. H. Weigl, Lab Chip, 2019, 19, 2486 DOI: 10.1039/C9LC00104B

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements