Issue 62, 2019

3(2H)-pyridazinone derivatives: a new scaffold for novel plant activators

Abstract

Due to the emergence of drug resistance, pesticide residue and environmental contamination, it is important to develop novel eco-friendly strategies to protect plants. Among them, plant activators have been gaining more and more attention. Herein, based on SHAFTS method, a new scaffold for novel plant activators was predicted and the discovery and structure–activity relationships of a series of 3(2H)-pyridazinone derivatives as novel plant activators were elucidated in detail. The vast majority of compounds exhibited excellent broad-spectrum induced resistance activity against tested diseases in vivo but no direct antimicrobial activity in vitro. Among them, compound 32 showed excellent efficacy against four pathogens and great potential as new plant activators in crop protection.

Graphical abstract: 3(2H)-pyridazinone derivatives: a new scaffold for novel plant activators

Supplementary files

Article information

Article type
Paper
Submitted
30 Leq 2019
Accepted
24 Dit 2019
First published
06 Xim 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 36204-36207

3(2H)-pyridazinone derivatives: a new scaffold for novel plant activators

Q. Shi, Y. Shi, K. Chang, J. Chen, Z. Zhao, W. Zhu, Y. Xu, B. Li and X. Qian, RSC Adv., 2019, 9, 36204 DOI: 10.1039/C9RA06892A

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