Issue 21, 2020

Stay positive: catalysis with 1,3,2-diazaphospholenes

Abstract

P-Hydrido 1,3,2-diazaphospholenes (DAPs) are a class of nucleophilic molecular hydrides capable of addition to a variety of substrates. They can be turned over with terminal reductants and emerged over the last few years as powerful and versatile catalysts. This review highlights developments made in understanding the chemistry of these unusual compounds and applying them in catalysis. An overview of the synthesis and important structural features of the DAPs is followed by a discussion of methodologies that exploit their chemistry in catalysis, including the rise of enantioselective reductions. We conclude with a brief analysis on the current limitations of the field and discuss how these might be overcome and which directions the field might take in the future.

Graphical abstract: Stay positive: catalysis with 1,3,2-diazaphospholenes

Article information

Article type
Review Article
Submitted
22 Qad 2020
Accepted
01 Way 2020
First published
03 Way 2020

Org. Chem. Front., 2020,7, 3521-3529

Stay positive: catalysis with 1,3,2-diazaphospholenes

J. H. Reed, J. Klett, C. Steven and N. Cramer, Org. Chem. Front., 2020, 7, 3521 DOI: 10.1039/D0QO00848F

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