Issue 31, 2022

H–F bond insertions into α-diazo carbonyl compounds

Abstract

A reaction for H–F bond insertion into α-diazo carbonyl compounds is reported. The protocol describes a simple reaction setup employing commercially available HF·pyr (Olah reagent) as the fluorine source. The method is rapid and practical, and allows access to a broad range of α-fluorinated carbonyl compounds in generally good yields.

Graphical abstract: H–F bond insertions into α-diazo carbonyl compounds

  • This article is part of the themed collection: New Talent

Supplementary files

Article information

Article type
Communication
Submitted
26 Nah 2022
Accepted
23 Cig 2022
First published
24 Cig 2022

Org. Biomol. Chem., 2022,20, 6178-6182

H–F bond insertions into α-diazo carbonyl compounds

L. S. Munaretto, R. D. C. Gallo, L. P. M. O. Leão and I. D. Jurberg, Org. Biomol. Chem., 2022, 20, 6178 DOI: 10.1039/D2OB00400C

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