Issue 19, 2023

Visible-light-induced dehydrogenative amidation of aldehydes enabled by iron salts

Abstract

A direct dehydrogenative amidation reaction of aldehydes and amines under a visible light mediated ligand-to-metal charge transfer (LMCT) process was described. In this protocol, aldehyde substrates were activated by photoinduced hydrogen atom abstraction (HAA), generating acyl chloride intermediates followed by nucleophilic addition of amines. The synthetic method furnishes good functional group tolerance and broad substrate scope toward both aliphatic and aromatic components.

Graphical abstract: Visible-light-induced dehydrogenative amidation of aldehydes enabled by iron salts

Supplementary files

Article information

Article type
Communication
Submitted
30 Xim 2022
Accepted
07 Nah 2023
First published
07 Nah 2023

Chem. Commun., 2023,59, 2771-2774

Visible-light-induced dehydrogenative amidation of aldehydes enabled by iron salts

H. Gao, L. Guo, Y. Zhu, C. Yang and W. Xia, Chem. Commun., 2023, 59, 2771 DOI: 10.1039/D2CC06507J

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