Issue 35, 2023

Ammonia surrogates in the synthesis of primary amines

Abstract

Primary amines are derivatives of ammonia in which one hydrogen atom is replaced by an alkyl or aryl group. Ammonia serves as the primary nitrogen source in amination reactions, and its utilization in solution or as a pure gas has witnessed notable advancements. However, the use of gaseous ammonia remains problematic in academic laboratory settings, while employing aqueous ammonia poses challenges in highly water-sensitive transformations. Consequently, the search for alternative sources of ammonia has garnered considerable attention among the organic chemistry community. This comprehensive literature review focuses on the use of ammonia surrogates in amination reactions, irrespective of the resulting intermediate. The review emphasizes the formation of the C–N bond and underscores the importance of generating intermediate products that can be readily transformed into primary amines through well-established reactions.

Graphical abstract: Ammonia surrogates in the synthesis of primary amines

Article information

Article type
Review Article
Submitted
31 Qad 2023
Accepted
08 Leq 2023
First published
08 Leq 2023

Org. Biomol. Chem., 2023,21, 7036-7051

Ammonia surrogates in the synthesis of primary amines

J. Urbiña-Alvarez, S. Rincón-Carvajal and D. Gamba-Sánchez, Org. Biomol. Chem., 2023, 21, 7036 DOI: 10.1039/D3OB01202F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements