Issue 37, 2023

Application and prospects of nucleic acid nanomaterials in tumor therapy

Abstract

Cancer poses a great threat to human life, and current cancer treatments, such as radiotherapy, chemotherapy, and surgery, have significant side effects and limitations that hinder their application. Nucleic acid nanomaterials have specific spatial configurations and can be used as nanocarriers to deliver different therapeutic drugs, thereby enabling various biomedical applications, such as biosensors and cancer therapy. In recent decades, a variety of DNA nanostructures have been synthesized, and they have demonstrated remarkable potential in cancer therapy related applications, such as DNA origami structures, tetrahedral framework nucleic acids, and dynamic DNA nanostructures. Importantly, more attention is also being paid to RNA nanostructures, which play an important role in gene therapy. Therefore, this review introduces the developmental history of nucleic acid nanotechnology, summarizes the applications of DNA and RNA nanostructures for tumor treatment, and discusses the development opportunities for nucleic acid nanomaterials in the future.

Graphical abstract: Application and prospects of nucleic acid nanomaterials in tumor therapy

Article information

Article type
Review Article
Submitted
17 Qas 2023
Accepted
08 Leq 2023
First published
04 Way 2023
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2023,13, 26288-26301

Application and prospects of nucleic acid nanomaterials in tumor therapy

W. Lu, T. Chen, D. Xiao, X. Qin, Y. Chen and S. Shi, RSC Adv., 2023, 13, 26288 DOI: 10.1039/D3RA04081J

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