Issue 45, 2023

Current trends in luminescence-based assessment of apoptosis

Abstract

Apoptosis, the most extensively studied type of cell death, is known to play a crucial role in numerous processes such as elimination of unwanted cells or cellular debris, growth, control of the immune system, and prevention of malignancies. Defective regulation of apoptosis can trigger various diseases and disorders including cancer, neurological conditions, autoimmune diseases and developmental disorders. Knowing the nuances of the cell death type induced by a compound can help decipher which therapy is more effective for specific diseases. The detection of apoptotic cells using classic methods has brought significant contribution over the years, but innovative methods are quickly emerging and allow more in-depth understanding of the mechanisms, aside from a simple quantification. Due to increased sensitivity, time efficiency, pathway specificity and negligible cytotoxicity, these innovative approaches have great potential for both in vitro and in vivo studies. This review aims to shed light on the importance of developing and using novel nanoscale methods as an alternative to the classic apoptosis detection techniques.

Graphical abstract: Current trends in luminescence-based assessment of apoptosis

Article information

Article type
Review Article
Submitted
25 Leq 2023
Accepted
18 Dit 2023
First published
30 Dit 2023
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2023,13, 31641-31658

Current trends in luminescence-based assessment of apoptosis

C. Moldovan, A. Onaciu, V. Toma, R. A. Munteanu, D. Gulei, A. I. Moldovan, G. F. Stiufiuc, R. I. Feder, D. Cenariu, C. A. Iuga and R. I. Stiufiuc, RSC Adv., 2023, 13, 31641 DOI: 10.1039/D3RA05809C

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