Issue 49, 2023

NH-1,2,3-triazoles as versatile building blocks in denitrogenative transformations

Abstract

The utilization of NH-1,2,3-triazoles as easily accessible building blocks in denitrogenative ring cleavage transformations with electrophiles to provide multifunctionalized nitrogen heterocycles and N-alkenyl compounds is reviewed. Leveraging the ready availability of NH-1,2,3-triazoles, these processes provide a convenient route to a range of pharmaceutically relevant heterocyclic cores and N-alkenyl compounds. The synthetic usefulness of in situ acylated NH-1,2,3-triazoles as viable alternatives to widely explored N-sulfonyl-1,2,3-triazoles in ring cleavage processes is highlighted.

Graphical abstract: NH-1,2,3-triazoles as versatile building blocks in denitrogenative transformations

Article information

Article type
Review Article
Submitted
05 Way 2023
Accepted
22 Xim 2023
First published
27 Xim 2023
This article is Open Access
Creative Commons BY license

RSC Adv., 2023,13, 34646-34651

NH-1,2,3-triazoles as versatile building blocks in denitrogenative transformations

V. Motornov and P. Beier, RSC Adv., 2023, 13, 34646 DOI: 10.1039/D3RA06045D

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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