Issue 50, 2023

Gilman reagent toward the synthesis of natural products

Abstract

With the ever-increasing scope of organocuprates, a well-established Gilman reagent has been considered as an unprecedented synthetic tool in modern organic chemistry. The broad research profile of the Gilman reagent (R2CuLi in THF or Et2O) is owing to its propensity to carry out three kinds of reactions, i.e., epoxide ring opening reactions, 1,4-conjugate addition reactions, and SN2 reactions in a regioselective manner. This review examines the applications of Gilman reagent in the total synthesis of both abundant and scarce natural products of remarkable synthetic pharmaceutical profile reported since 2011. The presented insights will be of a vital roadmap to general organic synthesis and it will contribute to the development of new natural products and their analogues in future drug discovery.

Graphical abstract: Gilman reagent toward the synthesis of natural products

Article information

Article type
Review Article
Submitted
29 Dit 2023
Accepted
19 Xim 2023
First published
04 Kax 2023
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2023,13, 35172-35208

Gilman reagent toward the synthesis of natural products

R. Munir, A. F. Zahoor, U. Nazeer, M. A. Saeed, A. Mansha, A. Irfan and M. U. Tariq, RSC Adv., 2023, 13, 35172 DOI: 10.1039/D3RA07359A

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