Issue 13, 2024

A graphene oxide-based sequential nanocatalyst for efficient tumor combination therapy

Abstract

Graphene oxide (GO) is a versatile and promising nanomaterial, and it can mimic peroxidase-like activity to generate hydroxyl radicals to kill tumor cells. However, the low biocompatibility and catalytic efficiency limit its application in tumor treatment. Here, we constructed a sequential catalytic nanocatalyst based on GO to overcome its drawbacks and improve the therapeutic effect. GO nanosheets were coated onto periodic mesoporous organosilica (PMOs) and then glucose oxidase (GOD) was modified on the surface to create PMO@GO-GOD. The GO-wrapping of the PMOs could reduce the damage of the two-dimensional GO nanosheets in the cell membrane. The loaded GOD decomposed glucose into H2O2 to continually supply the catalytic substrate for GO and thus enhanced its catalytic performance. Meanwhile, effective photothermal therapy could be achieved by GO shells. The administration of PMO@GO-GOD resulted in a remarkable antitumor effect with no obvious systemic toxicity.

Graphical abstract: A graphene oxide-based sequential nanocatalyst for efficient tumor combination therapy

Article information

Article type
Paper
Submitted
03 Nah 2024
Accepted
02 Cax 2024
First published
16 Cax 2024
This article is Open Access
Creative Commons BY-NC license

Mater. Adv., 2024,5, 5482-5493

A graphene oxide-based sequential nanocatalyst for efficient tumor combination therapy

Z. Yang, Y. Zhao, Z. Xu, R. Wang and Q. Wang, Mater. Adv., 2024, 5, 5482 DOI: 10.1039/D4MA00109E

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