Issue 38, 2017

Synthesis of functionalized indolizines via gold(i)-catalyzed intramolecular hydroarylation/aromatization of pyrrole-ynes

Abstract

A gold-catalyzed intramolecular hydroarylation/aromatization of pyrrole-ynes has been developed. This method provides a concise and straightforward route to functionalized indolizines through the construction of the pyridine ring of indolizines and also allows elaboration of its pyrrole moiety with or without functional groups. In addition, a wide variety of functional groups, such as aryl, alkenyl, alkynyl, pyridyl or thienyl groups, can be easily incorporated into the pyridine unit of the indolizine products under mild conditions. The utility of the indolizine products was demonstrated by their efficient transformations into various C3-functionalized indolizine derivatives.

Graphical abstract: Synthesis of functionalized indolizines via gold(i)-catalyzed intramolecular hydroarylation/aromatization of pyrrole-ynes

Supplementary files

Article information

Article type
Paper
Submitted
23 Leq 2017
Accepted
05 Way 2017
First published
05 Way 2017

Org. Biomol. Chem., 2017,15, 8119-8133

Synthesis of functionalized indolizines via gold(I)-catalyzed intramolecular hydroarylation/aromatization of pyrrole-ynes

X. Li, J. Zhao, X. Xie and Y. Liu, Org. Biomol. Chem., 2017, 15, 8119 DOI: 10.1039/C7OB02102J

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