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We have introduced a non-hormonal hyperglycemia treatment strategy by using an injectable glucose-responsive boronic acid- zwitterionic nanogel. The synthesized system, similar to an artificial liver, is capable of storing/releasing glucose at high/low blood glucose concentrations. In vivo performance revealed that the injection of the nanogels can effectively regulate blood glucose in type 1 diabetic rats for at least 6 hours.

Graphical abstract: Glucose regulation by modified boronic acid-sulfobetaine zwitterionic nanogels – a non-hormonal strategy for the potential treatment of hyperglycemia

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