Achieving strong coupling between emitters and cavity photons holds an important position in the light–matter interaction due to its applications such as polariton lasing, all-optical switches, and quantum information processing. However, room-temperature polaritonic devices with subwavelength dimensions based on strong light–matter coupling are difficult to realize using traditional emitter-cavity coupled systems. In recent years, coupled systems constructed from plasmonic nanostructures and transition metal dichalcogenides (TMDs) have shown their potential in achieving room-temperature strong coupling and robustness in the nanofabrication processes. This minireview presents the recent progress in strong plasmon–exciton coupling in such plasmonic–TMD hybrid structures. Differing from a broader scope of strong coupling, we focus on the plasmon–exciton coupling between excitons in TMDs and plasmons in single nanoparticles, nanoparticle-over-mirrors, and plasmonic arrays. In addition, we discuss the future perspectives on the strong plasmon–exciton coupling at few-excitons level and the nonlinear response of these hybrid structures in the strong coupling regime.