Polymeric engineering of AIEgens for NIR-II fluorescence imaging and detection of abdominal metastases of ovarian cancer in vivo

Xiaobo Zhou; Yuhan Zeng; Shijie Li; Ke Zhang; Lingfeng Zhao; Guo Li; Qi Wang; Haiwei Ji; Mingmin Wu; Jinxia Liu; Yuling Qin; Wei Feng; Fuyou Li; Li Wu

doi:10.1039/D3TB01750H

Polymeric engineering of AIEgens for NIR-II fluorescence imaging and detection of abdominal metastases of ovarian cancer in vivo†

Xiaobo Zhou,^a Yuhan Zeng,^a Shijie Li,^a Ke Zhang,^a Lingfeng Zhao,^a Guo Li,

^a Qi Wang,^a Haiwei Ji,

^a Mingmin Wu,^a Jinxia Liu,^a Yuling Qin,

*^a Wei Feng,

^b Fuyou Li

*^bc and Li Wu

*^a

Author affiliations

* Corresponding authors

^a School of Public Health, Nantong University, Nantong 226019, Jiangsu, China
E-mail: wuli8686@ntu.edu.cn, ylqin@ntu.edu.cn

^b Department of Chemistry & State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, China
E-mail: fyli@fudan.edu.cn

^c Institute of Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China

Abstract

A polymeric engineering design principle is proposed for the construction of small-sized (∼20 nm) NIR-II AIEgen-doped nanodots (AIEdots) with high brightness and prolonged circulation time in blood vessels. With the utilization of the as-designed NIR-II AIEdots, the successful achievement of high-resolution NIR-II fluorescence imaging of tumor vessels and precise detection of abdominal metastases of ovarian cancer has been attained.

This article is part of the themed collection: Journal of Materials Chemistry B Emerging Investigators

Journal of Materials Chemistry B

Polymeric engineering of AIEgens for NIR-II fluorescence imaging and detection of abdominal metastases of ovarian cancer in vivo†

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Polymeric engineering of AIEgens for NIR-II fluorescence imaging and detection of abdominal metastases of ovarian cancer in vivo

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