Advances in H2O2-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

Abstract

Hydrogen peroxide (H₂O₂) as a reactive oxygen species produced by cellular metabolism can be used in antitumor therapy. However, the concentration of intracellular H₂O₂ limits its application. Some materials could enhance the concentration of intracellular H₂O₂ to strengthen antitumor therapy. In this review, the recent advances in H₂O₂-supplying materials in terms of promoting intracellular H₂O₂ production and exogenous H₂O₂ supply are summarized. Then the mechanism of H₂O₂-supplying materials for tumor therapy is discussed from three aspects: reconstruction of the tumor hypoxia microenvironment, enhancement of oxidative stress, and the intrinsic anti-tumor ability of H₂O₂-supplying materials. In addition, the application of H₂O₂-supplying materials for tumor therapy is discussed. Finally, the future of H₂O₂-supplying materials is presented. This review aims to provide a novel idea for the application of H₂O₂-supplying materials in tumor therapy.