Issue 24, 2024

Lipid-based nanocarriers: an attractive approach for rheumatoid arthritis management

Abstract

Lipid nanoparticles (LNPs) have emerged as transformative tools in modern drug delivery, offering unparalleled potential in enhancing the efficacy and safety of various therapeutics. In the context of rheumatoid arthritis (RA), a disabling autoimmune disorder characterized by chronic inflammation, joint damage, and limited patient mobility, LNPs hold significant promise for revolutionizing treatment strategies. LNPs offer several advantages over traditional drug delivery systems, including improved pharmacokinetics, enhanced tissue penetration, and reduced systemic toxicity. This article concisely summarizes the pathogenesis of RA, its associated risk factors, and therapeutic techniques and their challenges. Additionally, it highlights the noteworthy advancements made in managing RA through LNPs, including liposomes, niosomes, bilosomes, cubosomes, spanlastics, ethosomes, solid lipid nanoparticles, lipid micelles, lipid nanocapsules, nanostructured lipid carriers, etc. It also delves into the specific functional attributes of these nanocarrier systems, focusing on their role in treating and monitoring RA.

Graphical abstract: Lipid-based nanocarriers: an attractive approach for rheumatoid arthritis management

Article information

Article type
Review Article
Submitted
09 avq 2024
Accepted
05 okt 2024
First published
01 noy 2024

Biomater. Sci., 2024,12, 6163-6195

Lipid-based nanocarriers: an attractive approach for rheumatoid arthritis management

M. B. Zewail, A. S. Doghish, H. M. El-Husseiny, E. A. Mady, O. A. Mohammed, A. M. M. Elbadry, A. S. Elbokhomy, A. Bhnsawy and W. A. El-Dakroury, Biomater. Sci., 2024, 12, 6163 DOI: 10.1039/D4BM01058B

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