A water-soluble Gd(III)-based fluorescence/T1-MR dual-modality probe for H2S sensing

Ho-Nam Mak; Xuanyi Lu; Siyu Pan; Yanjuan Gu; Lijun Jiang; Wing-Tak Wong

doi:10.1039/D4CC05042H

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A water-soluble Gd(iii)-based fluorescence/T₁-MR dual-modality probe for H₂S sensing†

Ho-Nam Mak,

^a Xuanyi Lu,^b Siyu Pan,^b Yanjuan Gu,

^a Lijun Jiang

*^ab and Wing-Tak Wong*^a

Author affiliations

* Corresponding authors

^a Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong SAR, China
E-mail: w.t.wong@polyu.edu.hk

^b Hubei Key Laboratory of Genetic Regulation & Integrative Biology, Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, School of Life Sciences, Central China Normal University, Wuhan 430079, China
E-mail: lijunjiang@ccnu.edu.cn

Abstract

We present a water-soluble fluorescence/MR dual-modality probe NBD[Gd] for H₂S detection. It showed 88.4% of fluorescence quenching and a 36% reduction in r₁ upon exposure to H₂S. It is readily uptaken by cells to sense the endogenous H₂S. Besides providing a bimodal H₂S imaging probe, our study also confirms the high H₂S level in CT26 cells and its functional consequence in promoting cell growth.

This article is part of the themed collection: 2024 Emerging Investigators

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Article information

DOI: https://doi.org/10.1039/D4CC05042H
Article type: Communication
Submitted: 27 sen 2024
Accepted: 04 noy 2024
First published: 06 noy 2024

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Chem. Commun., 2024, Advance Article

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A water-soluble Gd(III)-based fluorescence/T₁-MR dual-modality probe for H₂S sensing

H. Mak, X. Lu, S. Pan, Y. Gu, L. Jiang and W. Wong, Chem. Commun., 2024, Advance Article , DOI: 10.1039/D4CC05042H

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