Palladium-catalyzed cascade cyclization for the construction of spiro-N,O-acetals

Abstract

A facile Pd-catalyzed cascade cyclization of N-alkenylamine and pyruvic acids has been developed to construct spiro-N,O-acetals. This transformation was initiated by an intramolecular oxidative amination of alkenes, followed by hydrolysis to give a ketone intermediate, which further reacts with pyruvic acid to deliver the final spiro-N,O-acetals.