Amorphous metal–organic frameworks for drug delivery

Claudia Orellana-Tavra; Emma F. Baxter; Tian Tian; Thomas D. Bennett; Nigel K. H. Slater; Anthony K. Cheetham; David Fairen-Jimenez

doi:10.1039/C5CC05237H

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Amorphous metal–organic frameworks for drug delivery†

Claudia Orellana-Tavra,^a Emma F. Baxter,^b Tian Tian,^a Thomas D. Bennett,^b Nigel K. H. Slater,^a Anthony K. Cheetham^b and David Fairen-Jimenez

*^a

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* Corresponding authors

^a Department of Chemical Engineering & Biotechnology, University of Cambridge, CB2 3RA Cambridge, UK
E-mail: df334@cam.ac.uk

^b Department of Materials Science and Metallurgy, University of Cambridge, CB3 0FS Cambridge, UK

Abstract

We report the encapsulation of the hydrophilic model molecule calcein in the Zr-based MOF UiO-66, followed by amorphization of the framework by ball-milling. We show controlled release of calcein over more than 30 days, compared with the 2 day release period from crystalline UiO-66.

This article is part of the themed collections: Celebrating the 2017 RSC Prize and Award Winners and In celebration of Tony Cheetham’s 70th birthday

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Article information

DOI: https://doi.org/10.1039/C5CC05237H
Article type: Communication
Submitted: 25 iyn 2015
Accepted: 21 iyl 2015
First published: 21 iyl 2015

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Chem. Commun., 2015,51, 13878-13881

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Amorphous metal–organic frameworks for drug delivery

C. Orellana-Tavra, E. F. Baxter, T. Tian, T. D. Bennett, N. K. H. Slater, A. K. Cheetham and D. Fairen-Jimenez, Chem. Commun., 2015, 51, 13878 DOI: 10.1039/C5CC05237H

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Chemical Communications

Amorphous metal–organic frameworks for drug delivery†

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Amorphous metal–organic frameworks for drug delivery

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