Pyrene-based heparin sensors in competitive aqueous media – the role of self-assembled multivalency (SAMul)

Abstract

Amine-functionalised pyrene derivatives are reported and their ability to detect heparin via a fluorescent response determined – different responses are observed dependent on whether self-assembled multivalent binding between sensor and analyte takes place, and ratiometric heparin sensors which can detect this surgically-relevant polyanion in competitive media are reported.