Issue 47, 2019

Ni-catalyzed 1,2-benzylboration of 1,2-disubstituted unactivated alkenes

Abstract

Nickel-catalyzed 1,2-carboboration of alkenes is emerging as a useful method for chemical synthesis. Prior studies have been limited to only the incorporation of aryl groups. In this manuscript, a method for the 1,2-benzylboration of unactivated alkenes is presented. The reaction combines readily available alkenes, diboron reagents and benzylchlorides to generate synthetically versatile products with control of stereochemistry. The utility of the products as well as the mechanistic details of the process are also presented.

Graphical abstract: Ni-catalyzed 1,2-benzylboration of 1,2-disubstituted unactivated alkenes

Supplementary files

Article information

Article type
Edge Article
Submitted
21 avq 2019
Accepted
14 okt 2019
First published
22 okt 2019
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2019,10, 10944-10947

Ni-catalyzed 1,2-benzylboration of 1,2-disubstituted unactivated alkenes

S. Joung, A. M. Bergmann and M. K. Brown, Chem. Sci., 2019, 10, 10944 DOI: 10.1039/C9SC04199K

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