Issue 31, 2020

Antioxidant shape amphiphiles for accelerated wound healing

Abstract

Shape amphiphiles refer to a class of molecular conjugates composed by distinct building blocks with incommensurate shapes and chemical interactions. Whilst extensive efforts have been devoted to the solid state self-assembly and nanolithography applications of shape amphiphiles, only very limited examples of their usage in the biomedical field have been explored. In this work, we reported a series of gallic acid functionalized polyhedral oligomeric silsesquioxane (POSS)-based shape amphiphiles with various macromolecular architectures for efficient and accelerated wound healing. These antioxidant giant amphiphiles demonstrated good biocompatibility and strong free radical scavenging activity to prevent cell oxidative damage and then promote wound recovery. We describe these POSS-based antioxidant shape amphiphiles in an initial proof-of-concept study and propose that this family of functional giant amphiphiles will be useful in regenerative biomedicine.

Graphical abstract: Antioxidant shape amphiphiles for accelerated wound healing

Supplementary files

Article information

Article type
Paper
Submitted
03 mar 2020
Accepted
25 iyn 2020
First published
15 iyl 2020

J. Mater. Chem. B, 2020,8, 7018-7023

Antioxidant shape amphiphiles for accelerated wound healing

Z. Li, J. Zhang, Y. Fu, L. Yang, F. Zhu, X. Liu, Z. Gu and Y. Li, J. Mater. Chem. B, 2020, 8, 7018 DOI: 10.1039/D0TB00578A

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