Issue 31, 2020

Nanoparticle-based biosensors for detection of extracellular vesicles in liquid biopsies

Abstract

Tumor-derived extracellular vesicles have emerged as an alternative source of cancer biomarkers in liquid biopsies. Despite their clinical potential, traditional methods for isolation and analysis have hampered their translation into the clinic. The use of nanomaterial-based biosensors can speed up the development of analytical methods for quantifying extracellular vesicles in a specific, highly reproducible, robust, fast and inexpensive way. Here we review the utility of extracellular vesicles as a novel type of liquid biopsies and the recent advances in nanoparticle-based biosensors for their analysis. We aim to emphasise the limitations and challenges that hinder extracellular vesicle analysis using these biosensors and point out potential solutions.

Graphical abstract: Nanoparticle-based biosensors for detection of extracellular vesicles in liquid biopsies

Article information

Article type
Review Article
Submitted
01 apr 2020
Accepted
02 iyn 2020
First published
04 iyn 2020
This article is Open Access
Creative Commons BY license

J. Mater. Chem. B, 2020,8, 6710-6738

Nanoparticle-based biosensors for detection of extracellular vesicles in liquid biopsies

B. Martín-Gracia, A. Martín-Barreiro, C. Cuestas-Ayllón, V. Grazú, A. Line, A. Llorente, J. M. de la Fuente and M. Moros, J. Mater. Chem. B, 2020, 8, 6710 DOI: 10.1039/D0TB00861C

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