Synthetic approaches to 1,2,4-triazolo[5,1-c][1,2,4]triazin-7-ones as basic heterocyclic structures of the antiviral drug Riamilovir (“Triazavirin®”) active against SARS-CoV-2 (COVID-19)

Grigory A. Artem'ev; Vladimir L. Rusinov; Dmitry S. Kopchuk; Maria I. Savchuk; Sougata Santra; Eugeny N. Ulomsky; Grigory V. Zyryanov; Adinath Majee; Weijie Du; Valery N. Charushin; Оleg N. Chupakhin

doi:10.1039/D1OB02125G

Synthetic approaches to 1,2,4-triazolo[5,1-c][1,2,4]triazin-7-ones as basic heterocyclic structures of the antiviral drug Riamilovir (“Triazavirin®”) active against SARS-CoV-2 (COVID-19)

Grigory A. Artem'ev,^ab Vladimir L. Rusinov,^ab Dmitry S. Kopchuk,^ab Maria I. Savchuk,^ab Sougata Santra,

*^b Eugeny N. Ulomsky,^ab Grigory V. Zyryanov,^ab Adinath Majee,

^c Weijie Du,^d Valery N. Charushin^ab and Оleg N. Chupakhin

^ab

Author affiliations

* Corresponding authors

^a I. Ya. Postovskiy Institute of Organic Synthesis, UB of the RAS, 22 S. Kovalevskoy Str., Yekaterinburg, Russian Federation

^b Ural Federal University, 19 Mira str., Yekaterinburg, Russian Federation
E-mail: sougatasantra85@gmail.com

^c Department of Chemistry; Visva-Bharati (A Central University), Santiniketan 731235, India

^d Department of Pharmacology (State-Province Key Laboratories of Biomedicine Pharmaceutics of China, Key Laboratory of Cardiovascular research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, China

Abstract

Fragments of 1,2,4-triazolo[5,1-c][1,2,4]triazin-7-one are found in many compounds with various types of biological activities, including the antiviral drug Riamilovir (Triazavirin®), which shows activity against SARS-CoV-2 (COVID-19). Therefore, the development of convenient methods for the synthesis of new derivatives of 1,2,4-triazolo[5,1-c][1,2,4]triazin-7-one is always in demand. This review systematizes the information on the most common synthetic methods for constructing the 1,2,4-triazolo[5,1-c][1,2,4]triazin-7-one heterocyclic system.

This article is part of the themed collection: Synthetic methodology in OBC

Organic & Biomolecular Chemistry

Synthetic approaches to 1,2,4-triazolo[5,1-c][1,2,4]triazin-7-ones as basic heterocyclic structures of the antiviral drug Riamilovir (“Triazavirin®”) active against SARS-CoV-2 (COVID-19)

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Synthetic approaches to 1,2,4-triazolo[5,1-c][1,2,4]triazin-7-ones as basic heterocyclic structures of the antiviral drug Riamilovir (“Triazavirin®”) active against SARS-CoV-2 (COVID-19)

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