Recent advances in palladium-catalyzed C(sp3)/C(sp2)–H bond functionalizations: access to C-branched glycosides

Abstract

Over the recent decades, tremendous interest has developed in the transformation of complex substrates by C–H activation and functionalization. In particular, palladium-catalyzed directing and non-directing group-assisted C–H functionalization has emerged as a powerful avenue to access C-branched glycosides. Due to the extreme complexity, delicate functionalities, and high stability of C–H bonds, site-selective functionalization of carbohydrate under mild conditions is highly desirable. The purpose of this review is to cover most of the recent advances in palladium-catalyzed C(sp³) and C(sp²)–H bond functionalizations for the synthesis of C-branched glycosides along with future directions.