Visible-light-induced dehydrogenative amidation of aldehydes enabled by iron salts

Abstract

A direct dehydrogenative amidation reaction of aldehydes and amines under a visible light mediated ligand-to-metal charge transfer (LMCT) process was described. In this protocol, aldehyde substrates were activated by photoinduced hydrogen atom abstraction (HAA), generating acyl chloride intermediates followed by nucleophilic addition of amines. The synthetic method furnishes good functional group tolerance and broad substrate scope toward both aliphatic and aromatic components.