Peptide photowrapping of gold-silica nanocomposites for constructing MMP-responsive drug capsules for chemo-photothermal therapy

Hao Liu; Sijie He; Li-Ya Niu; Xue-Wang Gao; Ke Feng; Shumin Yang; Jianqun Shao; Wenhua Zhao; Nan Xie; Qing-Zheng Yang

doi:10.1039/D2CC06696C

Peptide photowrapping of gold-silica nanocomposites for constructing MMP-responsive drug capsules for chemo-photothermal therapy†

Hao Liu,‡^a Sijie He,‡^a Li-Ya Niu,

^b Xue-Wang Gao,^c Ke Feng,

^c Shumin Yang,^a Jianqun Shao,^a Wenhua Zhao,^a Nan Xie

*^a and Qing-Zheng Yang

^b

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* Corresponding authors

^a School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, P. R. China
E-mail: nanxie@ccmu.edu.cn

^b Key Laboratory of Radiopharmaceuticals Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China

^c Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, the Chinese Academy of Sciences, Beijing 100190, P. R. China

Abstract

A multifunctional undecapeptide, YYDPLGLADYY, was designed and synthesized for the photowrapping of silica-coated gold nanorods. The obtained nanocapsules, bearing a well-defined core–shell structure, were able to encapsulate a therapeutic drug, respond to an MMP-upregulated tumor microenvironment, and achieve NIR-triggered anticancer chemo-photothermal therapy with favorable efficacy.

This article is part of the themed collection: Photofunctional Materials and Transformations

Chemical Communications

Peptide photowrapping of gold-silica nanocomposites for constructing MMP-responsive drug capsules for chemo-photothermal therapy†

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Peptide photowrapping of gold-silica nanocomposites for constructing MMP-responsive drug capsules for chemo-photothermal therapy

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