Ultra-selective, ultra-clean 1D rotating-frame Overhauser effect spectroscopy†
Emma L.
Gates, 
a
Marshall J.
Smith,
a
Jonathan P.
Bradley,
b
Myron
Johnson,
b
Göran
Widmalm,
c
Mathias
Nilsson,
a
Gareth A.
Morris,
a
Ralph W.
Adams
*a
and
Laura
Castañar
*ad
a
Marshall J.
Smith,
a
Jonathan P.
Bradley,
b
Myron
Johnson,
b
Göran
Widmalm,
c
Mathias
Nilsson,
a
Gareth A.
Morris,
a
Ralph W.
Adams
*a
and
Laura
Castañar
*ad
Abstract
An ultra-selective 1D NMR experiment – GEMSTONE-ROESY – enables clear, unambiguous assignment of ROE signals in the not uncommon situation that traditional selective methods fail. Its usefulness is demonstrated in the analysis of the natural products cyclosporin and lacto-N-difucohexaose I, providing detailed insight into the structures and conformations of these molecules.
- This article is part of the themed collections: Celebrating the 200th Anniversary of the University of Manchester and Celebrating the scientific accomplishments of RSC Fellows
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