A giant macrocycle overcomes the post-treatment phototoxicity of photofrin through host–guest complexation

Abstract

Here we reported a supramolecular sequestration strategy to overcome the post-treatment phototoxicity of photofrin via direct host–guest complexation. Efficient recognition potency of a giant pentaphen[3]arene derivative could favor suppressing sunlight-induced skin damage through weakening the ability of complexed photofrin to generate singlet oxygen.