Long-term in vivo dissolution of thermo- and pH-responsive, 19F magnetic resonance-traceable and injectable polymer implants

Natalia Jirát-Ziółkowska; Martin Vít; Ondřej Groborz; Kristýna Kolouchová; David Červený; Ondřej Sedláček; Daniel Jirák

doi:10.1039/D4NA00212A

Long-term in vivo dissolution of thermo- and pH-responsive, ¹⁹F magnetic resonance-traceable and injectable polymer implants†

Natalia Jirát-Ziółkowska,

^ab Martin Vít,^a Ondřej Groborz,

^bc Kristýna Kolouchová,^c David Červený,^ad Ondřej Sedláček

^e and Daniel Jirák

*^ad

Author affiliations

* Corresponding authors

^a Radiodiagnostic and Interventional Radiology Department, Institute for Clinical and Experimental Medicine, Videnska 1958/9, 140 21 Prague, Czech Republic
E-mail: daniel.jirak@ikem.cz
Tel: +420-736467349

^b Institute of Biophysics and Informatics, First Faculty of Medicine, Charles University, Katerinska 1660/32, Prague 121 08, Czech Republic

^c Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovsky square 2, 162 06 Prague, Czech Republic

^d Faculty of Health Studies, Technical University of Liberec, Studentska 1402/2, Liberec 461 17, Czech Republic

^e Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, Hlavova 8, Prague, Czech Republic

Abstract

¹⁹F magnetic resonance (¹⁹F MR) tracers stand out for their wide range of applications in experimental and clinical medicine, as they can be precisely located in living tissues with negligible fluorine background. This contribution demonstrates the long-term dissolution of multiresponsive fluorinated implants designed for prolonged release. Implants were detected for 14 (intramuscular injection) and 20 (subcutaneous injection) months by ¹⁹F MR at 4.7 T, showing favorable MR relaxation times, biochemical stability, biological compatibility and slow, long-term dissolution. Thus, polymeric implants may become a platform for long-term local theranostics.

This article is part of the themed collection: Frontiers in Stimuli-Responsive Nanoplatforms: Pioneering Drug Delivery in Nanobiotechnology

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Article information

DOI: https://doi.org/10.1039/D4NA00212A
Article type: Paper
Submitted: 14 mar 2024
Accepted: 28 mar 2024
First published: 08 apr 2024
This article is Open Access

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Nanoscale Adv., 2024,6, 3041-3051

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Long-term in vivo dissolution of thermo- and pH-responsive, ¹⁹F magnetic resonance-traceable and injectable polymer implants

N. Jirát-Ziółkowska, M. Vít, O. Groborz, K. Kolouchová, D. Červený, O. Sedláček and D. Jirák, Nanoscale Adv., 2024, 6, 3041 DOI: 10.1039/D4NA00212A

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