Mineralization of macroaggregated albumin for accurate biodistribution evaluation of pre-radiotherapy

Abstract

Conventional macroaggregated albumin (MAA) often fails to accurately simulate the biodistribution of ⁹⁰Y microspheres in hepatic artery perfusion scintigraphy due to density mismatch. By mineralizing MAA, we developed lightly mineralized MAA (L-MAA) and highly mineralized MAA (H-MAA) with controlled densities, which enabled more accurate simulation of the biodistribution of resin and glass microspheres.