Issue 38, 2011

Glycosphingolipid synthesis employing a combination of recombinant glycosyltransferases and an endoglycoceramidase glycosynthase

Abstract

Glycosynthase mutants of Rhodococcus sp. endo-glycoceramidase II efficiently synthesize complex glycosphingolipids. Glycosyl fluoride donors may be assembled via sequential glycosyltransferase-catalysed glycosylation of lactosyl fluoride. Alternatively, lactosyl fluoride may be coupled to sphingosine prior to subsequent glycosylation steps.

Graphical abstract: Glycosphingolipid synthesis employing a combination of recombinant glycosyltransferases and an endoglycoceramidase glycosynthase

Supplementary files

Article information

Article type
Communication
Submitted
30 iyn 2011
Accepted
16 avq 2011
First published
30 avq 2011

Chem. Commun., 2011,47, 10806-10808

Glycosphingolipid synthesis employing a combination of recombinant glycosyltransferases and an endoglycoceramidase glycosynthase

J. R. Rich, A. Cunningham, M. Gilbert and S. G. Withers, Chem. Commun., 2011, 47, 10806 DOI: 10.1039/C1CC13885E

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