Issue 27, 2016

Synthesis of two ‘heteroaromatic rings of the future’ for applications in medicinal chemistry

Abstract

In a computational study, the 1H-pyrazolo[3,4-c]pyridin-5-ol and 2,6-naphthyridin-3-ol heterocycles were identified as unknown heteroaromatic ring systems of potential value for medicinal chemistry. Here we report robust and concise synthetic protocols that provide access to these two scaffolds on a multigram scale.

Graphical abstract: Synthesis of two ‘heteroaromatic rings of the future’ for applications in medicinal chemistry

Supplementary files

Article information

Article type
Communication
Submitted
13 yan 2016
Accepted
19 fev 2016
First published
22 fev 2016

RSC Adv., 2016,6, 22777-22780

Synthesis of two ‘heteroaromatic rings of the future’ for applications in medicinal chemistry

P. E. Silva Júnior, L. C. D. Rezende, J. P. Gimenes, V. G. Maltarollo, J. Dale, G. H. G. Trossini, F. S. Emery and A. Ganesan, RSC Adv., 2016, 6, 22777 DOI: 10.1039/C6RA01099G

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