A single-step multi-level supramolecular system for cancer sonotheranostics

Huirong Lin; Shuang Li; Junqing Wang; Chengchao Chu; Yang Zhang; Xin Pang; Peng Lv; Xiaoyong Wang; Qingliang Zhao; Junjie Chen; Hongmin Chen; Wen Liu; Xiaoyuan Chen; Gang Liu

doi:10.1039/C8NH00276B

A single-step multi-level supramolecular system for cancer sonotheranostics†

Huirong Lin,‡^a Shuang Li,‡^a Junqing Wang,

‡^a Chengchao Chu,^a Yang Zhang,^a Xin Pang,^a Peng Lv,^a Xiaoyong Wang,^a Qingliang Zhao,^a Junjie Chen,^b Hongmin Chen,

^a Wen Liu,^b Xiaoyuan Chen

^c and Gang Liu

*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, China
E-mail: gangliu.cmitm@xmu.edu.cn

^b School of Pharmaceutical Science, Xiamen University, Xiamen 361102, China

^c National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, USA

Abstract

A multi-level supramolecular system produced by single-step Fe³⁺-mediated ionic crosslinking self-assembly can overcome the critical issues of current sonodynamic therapy (SDT) and address the need to monitor therapeutic effects in vivo with a non-invasive approach. This rational design of organic sonosensitizer-based formulation shows great potential for clinical SDT against deep-seated cancer.

This article is part of the themed collection: Horizons Community Board Themed Collection – Nanobiomedicine

Nanoscale Horizons

A single-step multi-level supramolecular system for cancer sonotheranostics†

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A single-step multi-level supramolecular system for cancer sonotheranostics

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