Issue 26, 2020

An anti-infective hydrogel adhesive with non-swelling and robust mechanical properties for sutureless wound closure

Abstract

A non-swelling hydrogel adhesive is urgently needed in clinical application for wound closure; however, preparing a non-swelling hydrogel adhesive with superior mechanical and tissue adhesion properties remains a challenge. In this study, we developed a new family of non-swelling hydrogel adhesives composed of Pluronic F127 diacrylate, poly(ethylene glycol) diacrylate, modified sodium alginate, and tannic acid. Physical and biological properties of the hydrogels were systematically evaluated in vitro/vivo. The results indicated that the hydrogels exhibited non-swelling features, robust mechanical properties and good adhesion abilities toward various tissues. The hydrogels also exhibited good cytocompatibility and strong antibacterial activities against S. aureus and E. coli. Additionally, the hydrogel could be used for sutureless wound closure and displayed better advantages compared to sutures and commercial adhesive pads. The above results demonstrated that our non-swelling hydrogel adhesive with robust mechanical properties holds great promise for applications in clinical surgery.

Graphical abstract: An anti-infective hydrogel adhesive with non-swelling and robust mechanical properties for sutureless wound closure

Supplementary files

Article information

Article type
Paper
Submitted
08 mar 2020
Accepted
14 may 2020
First published
14 may 2020

J. Mater. Chem. B, 2020,8, 5682-5693

An anti-infective hydrogel adhesive with non-swelling and robust mechanical properties for sutureless wound closure

X. Du, Y. Hou, L. Wu, S. Li, A. Yu, D. Kong, L. Wang and G. Niu, J. Mater. Chem. B, 2020, 8, 5682 DOI: 10.1039/D0TB00640H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements