Issue 94, 2021

Supramolecular helices from helical building blocks via head-to-tail intermolecular interactions

Abstract

Supramolecular helices from helical building blocks represent an emerging analogue of the α-helix. In cases where the helicity of the helical building block is well propagated, the head-to-tail intermolecular interactions that lead to the helix could be enhanced to promote the formation and the stability of the supramolecular helix, wherein homochiral elongation dominates and functional helical channel structures could also be generated. This feature article outlines the supramolecular helices built from helical building blocks, i.e., helical aromatic foldamers and helical short peptides that are held together by intermolecular π–π stacking, hydrogen/halogen/chalcogen bonding, metal coordination, dynamic covalent bonding and solvophobic interactions, with emphasis on the influence of efficient propagation of helicity during assembly, favouring homochirality and channel functions.

Graphical abstract: Supramolecular helices from helical building blocks via head-to-tail intermolecular interactions

Article information

Article type
Feature Article
Submitted
05 sen 2021
Accepted
22 okt 2021
First published
22 okt 2021

Chem. Commun., 2021,57, 12562-12574

Supramolecular helices from helical building blocks via head-to-tail intermolecular interactions

X. Yan, P. Weng, D. Shi and Y. Jiang, Chem. Commun., 2021, 57, 12562 DOI: 10.1039/D1CC04991G

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